MERLN Institute for Technology-Inspired Regenerative Medicine

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Instructive Biomaterials Engineering (IBE)


Research at IBE is inspired and driven by materials science and engineering. The group aims at developing “smart”, instructive synthetic biomaterials for tissue and organ regeneration and for theranostics, with focus on inorganic materials.

IBE's main lines of research are:

  • Design and fabrication of biomaterials for regenerative medicine with closely controlled properties, by combining different material types and fabrication technologies.
  • Fundamental study of biological mechanisms behind interactions of biomaterials and cells/tissues, with the aim of designing and developing novel instructive biomaterials.
  • Application of bioinorganics as synthetic “growth factors”.
  • Application of biomineralization principles for developing new biomaterials for regeneration of skeletal tissues.
  • Development of platforms (e.g. based on microfluidics) for high throughput production of biomaterials and for screening of their interactions with the biological environment.
  • Development of multifunctional nanoparticles for imaging, site-specific drug delivery and controlled release.


Research Highlights

  • Engineering of calcium phosphate ceramics to be used as instructive biomaterials in regeneration of hard tissue and the use of bioinorganics as alternative synthetic “growth factors”. 
  • Patterning of bioceramics to study their interactions with biological systems in a controlled manner. 
  • Application of fundamental knowledge on biomineralization to develop improved strategies for regeneration of bone and bone-to-soft tissue interfaces.

  • Microfluidic technology for (high-throughput) production of inorganic biomaterials and for screening of their interactions with biological systems. 

  • Engineering of nanoparticles for targeted delivery of biomolecules, cell tracking and activation and for functionalization of structural biomaterials used in regenerative medicine.

  • Microtechnology for fabrication of high-resolution cell-instructive polymeric and composite surfaces. 


Further information and updates

Publication record: Scopus

Announcements and latest news: Twitter link

Available master projects: Google doc