MERLN Institute for Technology-Inspired Regenerative Medicine

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Principal Investigators

Principle Investigators

CTR

  • CTR
    Principal Investigator Assistant Professor

    Aart van Apeldoorn is currently an assistant Professor in the CTR department, and holds a similar position at the University Medical Center Groningen (UMCG) at the group of Paul de Vos. He aims to develop a bioartificial pancreas for extrahepatic islet transplantation. His research is focused on developing bioengineering technologies for pancreatic tissue engineering, islet delivery devices, and basic research on the islet extracellular matrix.

  • CTR
    Principal Investigator Assistant Professor

    Matt Baker's research interests include the synthesis and characterization of novel and dynamic materials to mimic the cellular environment and to influence cellular behavior. Of particular interest is the use of reversible supramolecular interactions (e.g. host-guest, supramolecular polymers, hydrogen bonding) to build these materials and the use of mechanochemistry to influence and measure cellular responses.

  • CTR
    Principal Investigator

    A long-term goal in medicine is to unleash the endogenous potential for human organ regeneration. Our group gathers scientists and engineers developing novel model systems of organs and organisms to investigate the design principles governing development and regeneration.

    Our research is grounded in fundamental stem cell biology using mouse and human embryonic and reprogrammed stem cells and in technologies using high throughput screenings in microsystems, single molecule imaging and single cell RNA sequencing in 3D model systems, organs and mouse embryos.

  • CTR
    Principal Investigator Associate Professor

    Roman Truckenmüller’s research focuses on micro- and nanoscale 3D polymer film forming and functionalization technologies and their biomedical applications, with a particular focus on engineering of complex artificial cellular microenvironments as advanced in vitro model systems using the aforementioned technologies.

  • CTR
    Principal Investigator Assistant Professor

    Dr. Stefan Giselbrecht graduated from the University of Saarbrücken, Germany, with a Diploma in Biology. He did his doctorate at the Institute of Microstructure Technology (Technical University of Karlsruhe, now Karlsruhe Institute of Technology, KIT, Germany) and the Institute of Medical Engineering and Biophysics (Research Center Karlsruhe, now KIT) under the supervision of Professor Volker Saile and received his Ph.D. degree from the Department of Mechanical Engineering.

  • CTR
    Principal Investigator Assistant Professor

    Vanessa LaPointe studied Biomedical Engineering at The Johns Hopkins University (USA). She did her doctoral research with Professor Molly Stevens at Imperial College London (UK), and received her PhD in 2013 on cell-substrate interactions in stem cell self-renewal and differentiation. As a postdoctoral researcher at the University of Twente (The Netherlands), she was awarded a fellowship from the Canadian Institutes of Health Research.

  • CTR
    Principal Investigator Full Professor

    Dr. Lorenzo Moroni's research interests aim at developing new biofabrication technologies to generate libraries of 3D scaffolds able to control cell fate. This passes through the design of biomaterials, 3D scaffolds, and surface properties to better understand cell-material interactions. 

cBITE

  • cBITE
    Principal Investigator Assistant Professor

    Aurélie Carlier’s research interests encompass the development and experimental validation of computational models of biological processes in the context of tissue regeneration and biomaterial interactions. In particular, she is interested in developing multiscale computational models where intracellular pathways are linked to the tissue scale via a cellular level. For the implementation of the models, she is applying a range of modelling techniques including hypothesis-based mechanistic models and data-driven gene network models.

  • cBITE
    Department Chair, Principal Investigator Full professor

    Jan de Boer is a full professor of applied cell biology and the chair of cBITE at the MERLN Institute, University of Maastricht, the Netherlands. Prof. de Boer obtained his PhD in the lab of Jan Hoeijmakers at the Erasmus MC Rotterdam in 1999 on mouse models for premature ageing, after which he worked as a postdoc at the MRC Laboratory of Molecular Biology in Cambridge, UK.

IBE

  • IBE
    Principal Investigator Assistant Professor

    Sabine van Rijt’s research aims to apply multifunctional nanoparticles in regenerative medicine. In particular, she aims to design and synthesize functionalized nanoparticles for imaging, site specific drug delivery, and controlled release purposes. The ability to modify specific features of physical, chemical and/or biological properties of, for example, stem cells opens the way to manipulate their actions in biomedical applications.

  • IBE
    Department Chair, Principal Investigator Full Professor

    The main focus of her research group is on inorganic biomaterials for use in tissue regeneration or as nanoparticles for theranostics, and on high-throughput production and screening approaches for biomaterials based on microfluidics.

  • Principal Investigator Professor of Entrepreneurship in Healthcare

    Marianne van der Steen is Professor of Entrepreneurship in Healthcare at the Faculty of Health, Medicine and Life Sciences, Maastricht University (MERLN). Marianne is the founding director of the MBI Life Sciences and Health, a global accelerator program for life sciences start-up companies. At MERLN, Marianne is responsible for biomedical entrepreneurship education and valorization from the lab to a spin-off company. Her research focus is on biomedical entrepreneurship, specifically on the growth of ventures & transformation of venture management teams.